Ramipril: Uses, Dosage, Storage, and Side Effects

Generic Name: ramipril

Brand Name: Altace

Drug Class: ACE Inhibitors

What is Ramipril?

Ramipril is a member of the angiotensin-converting enzyme (ACE) inhibitor class of drugs, playing a vital role in managing high blood pressure, and heart failure, and preventing kidney failure linked to conditions like hypertension and diabetes. In this informative guide, we’ll delve into the specifics of ramipril, exploring its uses, dosage, potential side effects, and essential considerations.

Uses of Ramipril

Ramipril acts as an ACE inhibitor, targeting the enzyme responsible for producing angiotensin II. This chemical induces the contraction of muscles in arteries, including those in the heart, leading to elevated blood pressure. By reducing the production of angiotensin II, ramipril helps relax arterial muscles, widen arteries, and subsequently lower blood pressure.

For individuals with congestive heart failure, the benefits are particularly pronounced. Ramipril eases the workload on the heart, enhancing blood flow and oxygen supply to the heart muscles. Additionally, in the kidneys, it counteracts the narrowing of arteries caused by angiotensin II, mitigating damage resulting from high blood pressure. The FDA approved ramipril in 1991, acknowledging its efficacy in addressing these cardiovascular concerns.

Side Effects of Ramipril

Ramipril is generally well-tolerated, with mild and transient side effects. The most common include a dry, persistent cough and increased potassium levels in the blood (hyperkalemia), both of which typically subside upon discontinuation of the medication.

Other notable side effects encompass abdominal pain, constipation, diarrhea, rash, dizziness, fatigue, headache, loss of taste, loss of appetite, nausea, vomiting, fainting, and numbness or tingling in the extremities.

Dosage Guidelines

The prescribed dosage for ramipril varies based on the condition being treated. For hypertension, a daily dose of 2.5-20 mg, either as a single dose or two divided doses, is typical. Patients on diuretics or with reduced kidney function may necessitate lower doses. In heart failure cases, initiation often involves 1.25-2.5 mg twice daily, gradually titrating up to 10 mg once daily or 5 mg twice daily. The prevention of heart attacks and strokes may warrant a daily dosage ranging from 2.5-10 mg.

Pregnancy and Breastfeeding Precautions

Ramipril, like other ACE inhibitors, poses a risk to the fetus and is contraindicated during pregnancy. Women who are breastfeeding should also avoid the use of ramipril due to potential harm to the infant.

Additional Information

Ramipril is available in capsule or tablet form, with dosages of 1.25, 2.5, 5, and 10 mg. Proper storage entails keeping tablets and capsules at room temperature, ranging from 15°C to 30°C (59°F to 86°F).


In conclusion, ramipril is a valuable ACE inhibitor with applications in treating congestive heart failure, and hypertension, and preventing related complications. Understanding its uses, potential side effects, and proper dosage is crucial for both patients and healthcare providers. If considering ramipril, consult with your healthcare professional to determine the most appropriate course of treatment tailored to your specific health needs.

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