Lacosamide is a prescription medication used to treat epileptic conditions, including partial-onset seizures and primary generalized tonic-clonic seizures. Seizures are caused by abnormal electrical activity in the brain, and lacosamide works by reducing the potential for this abnormal activity. It is available in oral tablet, capsule, and solution forms, as well as an intravenous injection solution.
Lacosamide is FDA-approved for monotherapy or adjunctive therapy for partial-onset seizures in adults and children aged one month or older, and adjunctive therapy for primary generalized tonic-clonic seizures in adults and children 4 years and older. Off-label uses include status epilepticus.
Lacosamide may cause serious side effects, including suicidal thoughts and behavior, dizziness, and cardiac rhythm and conduction abnormalities. Common side effects include headache, drowsiness, tremor, and balance disorder.
The dosage of lacosamide varies depending on the patient’s age and the specific condition being treated. The dosage may need to be adjusted for patients with renal or hepatic impairment.
Lacosamide may interact with other medications, so it is essential to inform your doctor of all prescription and over-the-counter medications you are currently taking. There is insufficient information to identify a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes with the use of lacosamide during pregnancy. However, animal reproductive studies have shown that lacosamide can cause fetal harm if used during pregnancy. Lacosamide is present in breastmilk and can cause excessive sedation in breastfed infants.
It is crucial to take lacosamide exactly as directed by your doctor and not to abruptly discontinue the medication. Lacosamide may induce or worsen depression and suicidal thoughts and behavior, so it is essential to seek support from family, friends, and healthcare providers if you experience any changes in mood or behavior while taking this medication.