Allopurinol – Uses, Side Effects, Precautions, and More

Common Brand(s): Zyloprim
Generic Name(s): Allopurinol


Allopurinol is utilized for treating gout and certain types of kidney stones. It’s also prescribed to prevent elevated uric acid levels in patients undergoing cancer chemotherapy, where increased uric acid results from the dying cancer cells. Allopurinol works by reducing the body’s production of uric acid, crucial in preventing gout and kidney issues.

Usage/Dosage of Allopurinol

Take this medication orally as directed by your doctor, usually once daily. To minimize stomach upset, consume it after a meal. If your dosage exceeds 300 milligrams per day, follow your doctor’s instructions to divide the dose into several smaller portions throughout the day.

Ensure you drink a full glass of water with each dose and maintain hydration by drinking at least 8 more glasses (8 ounces each) daily. If your doctor advises reduced fluid intake for medical reasons, seek further guidance. Your doctor may also provide instructions on decreasing urine acidity, such as avoiding excessive ascorbic acid (vitamin C).

Dosage depends on your medical condition and response to treatment. Consistency in medication use is essential for maximum benefits. To remember, take it at the same time(s) each day.

Allopurinol For Gout Treatment

It might take several weeks for the medication to show effects. Initially, gout attacks may increase as the body eliminates excess uric acid. Allopurinol doesn’t relieve pain from gout; thus, continue your prescribed gout attack medicines as directed by your doctor.

Inform your doctor if your condition persists or worsens.

Side Effects of Allopurinol

Potential side effects may include stomach upset, nausea, diarrhea, or drowsiness. If any of these symptoms persist or worsen, inform your doctor or pharmacist promptly.

Contact your doctor immediately if you experience serious side effects, including arm/leg numbness or tingling, easy bleeding/bruising, signs of kidney problems, signs of liver disease, unusual weight loss, eye pain, vision changes, or severe allergic reactions.

Precautions for Using Allopurinol

Before taking allopurinol, discuss any allergies you have, especially any previous severe reactions to the drug. This product may contain inactive ingredients that could cause allergic reactions or other issues. Check with your pharmacist for more information.

Inform your doctor about your medical history, particularly if you have liver or kidney disease, diabetes, high blood pressure, or follow unique diets like fasting.

Avoid alcohol or cannabis consumption, as it may exacerbate drowsiness caused by the drug. Refrain from driving or using machinery if affected by these side effects.

Discuss medication usage with your doctor if you’re pregnant or nursing. Allopurinol passes into breast milk and may affect the nursing infant.


Notify your doctor of all the products you use (prescription/nonprescription drugs, herbal products) to avoid potential drug interactions.

Allopurinol Storage

Store at room temperature, shielded from light and moisture. Ensure medications are out of reach of children and pets. Dispose of the product safely when expired or no longer needed.


Do not share this medication with others. Attend all medical and lab appointments as directed while using this medication. If you miss a dose, take it as soon as you remember; however, if it’s nearing your next dose, skip the missed one. Don’t double up the dose.

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