4KScore Test

In the realm of prostate cancer screening, the 4KScore test has emerged as a promising diagnostic tool, utilizing a unique combination of biomarkers to assess the risk of aggressive prostate cancer. This article delves into the intricacies of the 4KScore test, shedding light on its components, role in screening, and its differentiating factors from other tests like the Prostate Health Index (PHI).

What is the 4K Biomarker?

The 4KScore test hinges on the evaluation of four distinct prostate-specific kallikreins present in the blood—total PSA, free PSA, intact PSA, and human kallikrein 2 (hK2). Through a sophisticated algorithm, the test computes an individual’s percentage risk of harboring an aggressive form of prostate cancer.

What does 4Kscore Test measure?

The test centers its measurements on the levels of total PSA, free PSA, intact PSA, and hK2 in the bloodstream. These metrics collectively contribute to a comprehensive understanding of a patient’s prostate health.

What is the role of 4Kscore test in Prostate Cancer Screening?

An instrumental facet of the 4KScore test is its role in guiding biopsy decisions. By ascertaining the patient’s probability of possessing aggressive prostate cancer with a Gleason score of 7 or higher, the test aids physicians in tailoring a personalized approach. Incorporating clinical information such as age, digital rectal exam findings, and prior biopsy history, the test provides a risk percent score ranging from less than 1% to over 95%.

Minimizing Unnecessary Biopsies

Empirical studies have demonstrated the efficacy of the 4KScore test in predicting the detection of Gleason 7 or higher prostate cancer. Notably, up to 30%–58% of biopsies could potentially be avoided, given that only a fraction of men undergoing biopsy exhibit a Gleason score of 7 or higher. This reduction in unnecessary biopsies underscores the test’s clinical utility.

Cost Considerations

The 4KScore test comes with a price tag of $760.00. For individuals seeking clarification on the test’s cost or requiring additional information, a toll-free helpline is available at 1-855-452-4554.

Comparison 4KScore Test with the PHI Test

While both the 4KScore and the Prostate Health Index (PHI) are valuable tools in prostate cancer assessment, no published studies directly compare the two. The PHI, relying on total PSA, free PSA, and (-2)proPSA, excels in estimating the presence of overall and high-grade prostate cancer. In essence, these tests are considered complementary, with PHI predicting prostate cancer risk and the 4KScore focusing on the risk of high-grade prostate cancer.


The 4KScore test stands at the forefront of prostate cancer diagnostics, providing a nuanced understanding of an individual’s risk profile. Its ability to minimize unnecessary biopsies and offer a tailored risk assessment makes it a valuable asset in the evolving landscape of prostate cancer screening.


  1. Loeb, S., and W. Catalona. “The prostate health index: a new test for the detection of prostate cancer.” Therapeutic Advances in Urology 6.2 (2014): 74-77.
  2. Parekh, D.J., et al. “A multi-institutional prospective trial in the United States confirms that the 4Kscore accurately identifies men with high grade prostate cancer.” European Urology 68.3 Sept. 2015: 464-470.
  3. Punnen, S., et al. “Finding the Wolf in Sheep’s Clothing: The 4Kscore Is a Novel Blood Test That Can Accurately Identify the Risk of Aggressive Prostate Cancer.” Reviews in Urology 17.1 (2015): 3-13.

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